IV inj 40 mg dose: Administer reconstituted soln over a period of at least 3 min. 20 mg dose: ½ of reconstituted soln over a period of approx 3 min.
IV infusion 40 mg dose: Administer reconstituted soln over a period of 10-30 min. 20 mg dose: ½ of reconstituted soln over a period of 10-30 min. 80 mg bolus dose: Continuous IV infusion over 30 min. 8 mg/hr dose: Continuous IV infusion over a period of 71.5 hr.
Gastric antisecretory treatment when oral route is not possible 20-40 mg once daily.
Reflux oesophagitis 40 mg once daily.
Symptomatic reflux disease, gastric ulcers healing associated w/ NSAID therapy, prevention of gastric & duodenal ulcers associated w/ NSAID therapy 20 mg once daily.
Maintenance of haemostasis & prevention of gastric & duodenal ulcer rebleeding Following therapeutic endoscopy, administer 80 mg as bolus infusion, followed by continuous IV infusion of 8 mg/hr given over 3 days (72 hr). Parenteral treatment period should be followed by acid-suppression therapy w/ esomeprazole 40 mg tab once daily for 4 wk.
Severe hepatic impairment GERD Max daily dose: 20 mg.
Bleeding ulcers Initially 80 mg bolus, then continuous infusion of 4 mg/hr for 71.5 hr.
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